Iain Duncan Smith will declare that work is "good for your health" and can help people recover from illness as he unveils plans for more reforms in the welfare system.
Sickness benefits assessments need overhauling to increase the number of claimants who get back into employment, the Work and Pensions Secretary will say.
Too many people with "common" mental illnesses are reliant on state payouts when they could be earning a wage, he will also suggest.
Mr Duncan Smith has already pushed through a number of controversial reforms of the welfare system but will accuse critics of government efforts to get claimants on sickness benefits into work of "scaremongering", insisting the most vulnerable will always be protected.
In a speech, he will say: "There is one area on which I believe we haven't focused on enough - how work is good for your health.
"Work can help keep people healthy as well as help promote recovery if someone falls ill.
"So, it is right that we look at how the system supports people who are sick and helps them into work.
"Let me be clear: a decent society should always recognise that some people are unable to work as a result of physical or mental ill health - or both.
"It is right that we protect these most vulnerable people in our society. That support is there.
"For, despite the scaremongering, it is worth reflecting on the fact that we in this country spend more on sick and disabled people than the OECD (Organisation for Economic Co-operation and Development) average."
He will add: "We know there remains a gap between the employment rate of disabled and non-disabled people.
"We want to ensure everyone has the opportunity to transform their lives for the better by getting into work.
"That's why as part of our one nation approach, we have committed to halving this gap."
The work capability assessment system that determines if someone will receive the employment and support allowance (ESA) has been dogged by controversy since its introduction under Labour.
Mr Duncan Smith will say that ESA was supposed to reduce the number of people on incapacity benefits by one million but since 2010 there has been a fall of just 90,000 and plans to reform the process will now be drawn up.
Nearly one in four jobseeker's allowance claimants have a common mental health condition and need more support to find, and stay, in employment, he will add.
Mr Duncan Smith will say: "ESA may have been designed with the right intentions but at its heart lay a fundamental flaw. It is a system that decides that you are either capable of work or you are not.
"Two absolutes equating to one perverse incentive - a person has to be incapable of all work or available for all work.
"This needs to change - things are rarely that simplistic. We need to look at the system and in particular the assessment we use for ESA - and I want to look at changing it so that it comes into line with the positive functioning of Universal Credit, and as such is better geared towards helping to get people prepared for and into what work they may be capable of, rather than parking them beyond work.
"We need a system focused on what a claimant can do and the support they'll need - and not just on what they can't do."
He will add: "Nearly 11 million adults in the UK have a common mental health condition and people are much more likely to fall out of work if they do.
"We also know that being out of work for four weeks or more can actually effect people's mental health, even if the original reason for ill health was a physical one."