Krokodil, which costs £5 per hit on the street, contains a mix of codeine, gasoline, paint thinner, industrial cleaning oil, and alcohol.
It is a drug for the poor, and its results are catastrophic.
A user's muscles, tendons and bones can become exposed as the drug eats away at the flesh, while the toxic concoction causes abscesses and gangrene on the skin – making it look as scaly as that of crocodiles and earning it its name.
Shockingly, addicts have a life expectancy of less than a year, doctors have warned.
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Now, two American users of Krokodil - which originated in Russia – have revealed their battle with the devastating drug and how its noxious effects have left their bodies ruined.
Amber and Angie Neitzel, from Joliet, Illinois, say they have been abusing the toxic cocktail for around a year and a half – suggesting the deadly drug has spread to the streets of the U.S. for much longer than originally feared.
“It almost starts like a burn from a cigarette,” Amber Neitzel, 26, told ABC’s WLS-TV.
”It starts purple and then goes into a blister after five or six days.”
But, despite their horrific deformities, the sisters told MailOnline they preferred the new drug because it was a tenth of the price of normal heroin and also gave them an incredibly intense high.
"You can get marks and bleeding from shooting up heroin, but nothing like this. They are deep holes and the skin is just rotting away. It's hard to describe how revolting they are."
Amber, a mother-of-two described how those around her had been affected by the drug.
"This is a really bad problem. This drug is real, it rots you away from the inside and attacks your organs.
"I have been using for 18 months and I know it's done some permanent damage. I will be lucky if I live another ten years from now.
"My boyfriend actually had maggots coming out of his leg. I know people don't want to hear stuff like that, but it is really happening out here."
A doctor who has said he is treating victims of the drug in the US, including Amber and Angie, told The Chicago Sun-Times: “If you want to kill yourself, this is the way to do it.”
Krokodil “rots the skin from the inside out,” Dr. Abhin Singala said this week.
"It is a horrific way to get sick. The smell of rotten flesh permeates the room."
While the drug has been in Russia for at least a decade, with around 30,000 people in the country thought to die from the affects of the drug every year, Krokodil is only now making its way to the states. The first reported instances of the intravaneous drug cropped up in Arizona roughly two weeks ago.
Worryingly, a British doctor believes he may have come across a case in the UK.
Dr Allan Harris, a GP in Gloucester, wrote in an article for The Independent that the man was homeless and in his 30s.
"There was essentially a crater in his arm and you could see the bone and tendons," he wrote.