The 25-year-old, whose real name is Zoe Sugg, shot to fame thanks to her beauty tutorials and now has more than 9.1 million subscribers on YouTube and 3.7 million followers on Twitter.
But the star wants her young fans to know that you can't always see what goes on behind closed doors.
"A lot of young people look at me and think: 'She has the perfect life. She's got the boyfriend, the house, the dog, the book, the successful YouTube channel'," Zoella said in an interview with Seventeen magazine.
"Not everything is perfect… Sometimes I have days where I don't want to leave my bed, or I'll have multiple panic attacks."
The YouTube star went on to reveal she began to film herself putting on makeup because she was seeking a distraction from her anxiety. She described the process of creating a video diary as "comforting".
Despite being famous around the world, travelling is something that continues to worry Zoella.
"It was only when things started happening. ‘You’ve been invited to an event in London - hop on the train!’ That’s out of my comfort zone," she added.
This isn't the first time the vlogger has shared her experiences of anxiety with her fans.
In 2014 she bravely filmed herself in tears mid-panic attack, to tell her followers: "Sometimes, it all gets a bit too much."