Our underfunded NHS now faces potentially catastrophic financial consequences of Brexit. But the most immediate threat to the NHS is not financial but human: the risk that members of its most precious, most undervalued asset - its workforce - may now wonder what on earth they are doing here.
Prime Ministers who are primarily administrative in nature often flourish and are good for settled times in our history. But last Thursday's vote means that the United Kingdom now needs the kind of inspirational leadership that very few can actually offer. As David Cameron said, a new heading requires a new captain. That new heading involves sailing through some potentially very choppy waters, so we will need a captain with real character, plenty of foresight and the vision to carry the nation forward.
This campaign proved it is not enough to win support in London and the big cities - the heart of Jeremy's support. The voices of towns in former industrial, coastal and rural areas across England and Wales, who feel left behind, was heard loud and clear... The uncomfortable truth must be faced, or Labour will not rebuild our relationship with many of our longstanding voters. During the post-mortem, Labour MPs, MEPs, councillors and members will have to decide whether Jeremy can reassure and re-unite our supporters beyond London and the major cities. And do so, before a possible autumn general election against a new Tory leader.
The process of choosing David Cameron's successor will take time and will undoubtedly cause further issues within government. The negotiations about how to negotiate will take time, and may themselves be difficult.
The good news then is that this is not likely to be a banking crisis like that which we witnessed in 2008. The bad news though is what comes after the initial 'shock' has passed. Because even if the Bank of England looks set to be able to weather the immediate storm inflicted by stock markets, the longer term implications look far less certain and far more challenging.
I am devastated and I am angry. Today we woke to a deeply divided country. Nigel Farage's vision for Britain has won this vote, but it is not a vision I accept. An institution that we built, that delivered peace, that promoted equality, kept us safe and opened the doors of opportunity, will no longer play part of Britain's future. With this vote, the very fabric of our country has changed. The whole fabric of Europe has been changed. Our fight for an open, optimistic, hopeful, diverse and tolerant Britain is needed now more than ever. Together we will continue to make the case for Britain's future with Europe, a future millions of people have voted for.
We could yet see a second re-negotiation followed by a second referendum in which Prime Minister Johnson successfully campaigns for Remain, having achieved his primary goal by becoming Prime Minister.
Britain is at a crossroads: not the crossroads we wanted, but the one we have nonetheless. The choice before Remainers now is to allow this to usher in a new era of neoliberal, xenophobic politics that works for the few not the many, or to fight for a better, more inclusive, more equal Britain.
GMB advocated an 'angry remain' vote. It was a pragmatic vote that said, on balance, we'd be better off in. It was based on the defence of the workplace rights we've fought for via the EU for decades. It recognised the problems with the EU and pledged to fight to fix them. But the country did not agree - too many couldn't bring themselves to vote for what they saw as a failing status quo.
The only positive I can draw from this is that Jeremy Corbyn cannot possibly survive as leader of the Labour Party. It was Labour voters that lost this referendum. Corbyn's leadership and ability, even willingness, to convey his message were non-existent. He woefully failed to connect with voters in the traditional Labour heartlands who rejected his leadership emphatically, opting for Leave perhaps in their millions.
What saddens me most of all is that many of the people who voted Leave yesterday will be the ones who suffer most as a result of their decision. The foreigners who they believe have taken their jobs and houses will not suddenly be deported; the over-crowded schools and GPs' surgeries will not suddenly empty; the out-of-touch elites whom they blame for their misfortunes will not suddenly hand over power to people's tribunes... What we need now is a leader who can heal the referendum wounds and speak across the national divide. David Cameron's days as prime minister are clearly numbered; Boris Johnson will never be a convincing leader, however hard he tries, any more than Jeremy Corbyn will be. We enter an age of uncertainty, cast adrift into turbulent waters with no one at the tiller.
The core message is: the UK has an amazing deal, If we leave, it may never be available again. If Brexit is not the dream that is promised we would be cap in hand, accepting whatever is offered. We have a respected and powerful voice, and a vital part to play in a much bigger world stage than that of Little Britain
With most of the polls saying it's too close to call, turnout is going to be a huge factor on Thursday. As I've spoken about many times before, there is a clear and alarming demographic divide, with young people much less likely to come out and vote than older people. For me the real fear is that the older generation will end up, by default, making this decision for the younger generation - on whose lives this referendum will have a far greater impact. I hope this show will provide all voters - of all ages - with the confidence to make an informed judgement for themselves come polling day. What it won't tell you is how to vote - that's up to you. Also, I still haven't decided. Must do that.
This is not the kind of country I want Britain to be. We can and should be a tolerant, open, outward-looking country. Our politics should be a lively, energetic exchange of views, where ideas are robustly challenged in a climate that respects the individuals involved in the debate.
The referendum is almost upon us and there have been many arguments made on both sides. When you're talking about the future it's difficult to say with any certainty what will happen whatever the result because none of us have a crystal ball. So it is important at this point in the debate to think about what it is we actually know for certain and what questions are still unanswered.
Many thousands of words have been written on the subject of how the UK will fare should we vote to leave the European Union on 23 June... However, it is likely that many fewer words have been written describing the balanced view - that while there will undoubtedly be some uncertainty, it is inevitable that there will be some very substantial economic benefits too.