With a deafening roar from the crowd, Britain's 'Weirwolf' David Weir took gold in the men's T54 marathon, his fourth gold of the Games.
Weir's marathon takes ParalympicsGB's medals to 119, with 34 golds. GB's Shelley Woods took silver in the women's marathon.
The 33-year-old, whose trademark "Weirwolf" howl has become one of the sounds of the Games, was cheered on by thousands as he sped past some of the world's most recognisable landmarks in the race.
The Men's T54 Marathon makes its way into Parliament Square, London
He timed his sprint finish to perfection to take the title in one hour 30.20 minutes.
The home favourite was in a leading group of six racers which broke away early on, content to sit just off the front.
Weir was second behind Switzerland's Marcel Hug in a leading pack of three, also including Australian defending champion Kurt Fearnley with three miles to go.
Weir came into view of the finishing straight in the lead and pulled away from his rivals to complete a glorious end to a spectacular week.
David Weir of Great Britain crosses the finishing line to win the T54 Men's Marathon
Speaking after the momentous win, a clearly-exhausted Weir revealed he felt as though he was "going to die" just five miles in.
He said: "The first six miles were the hardest.
"I thought I was going to die. I felt like I had no energy and thought 'if they keep this speed up, I won't last another mile'."
Weir is unbeaten in this year's Games, winning all the wheelchair races in which he has competed and earning a place in the nation's hearts while doing so.
The route is different to that of the traditional London Marathon, featuring one 2.2-mile and four eight-mile laps, taking in sights such as St Paul's Cathedral, Buckingham Palace and the Houses of Parliament.
Weir said before he began that the course was a tough one to crack: "The course is very twisty. It's not going to be banging out top speeds for a long while so hopefully I can get the endurance and get through it. We'll see."
The win could be Weir's last ever Paralympic appearance, after he admitted he is undecided about whether to compete as a 37-year-old athlete in the 2016 Rio de Janeiro Games.