A 19-year-old man has been arrested on suspicion of causing death by dangerous driving.
Police were called to Liverpool Road in Irlam, Salford, at 8pm yesterday after a Vauxhall Corsa van had been in collision with a 22-year-old man.
The man, named by police as Reece Duffy from Irlam, was taken to hospital but died in the early hours of Saturday.
A spokesman for Greater Manchester Police said: "A 19-year-old man has been arrested on suspicion of causing death by dangerous driving and remains in custody.
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"The road has now been reopened.
"Anyone with any information is asked to call police on 0161 856 4741."