Charles tried his hand at being a sci-fi baddie during a visit to the BBC's studios in Cardiff.
Using a microphone plugged into a voice modulator, he uttered the Daleks' famous "exterminate" catchphrase - leaving the show's writer Stephen Moffat thoroughly impressed.
He said: "I haven't thought about how I could weave a meeting between the Doctor and the royal family. But Prince Charles's attempt at being a Dalek was great.
"There would be a part in the show for him if he wanted it."
According to actor Matt Smith, who is due to stand down as the current Doctor, the Prince has been a secret fan of the show since he was 15. Matt and co-star Jenna-Louise Coleman gave the future king and his wife Camilla a tour of the show's set in Cardiff.
As well as getting to grips with a sonic screwdriver, the Prince stepped inside the famous Tardis. The qualified helicopter pilot got to grips with its controls, while the Duchess of Cornwall pulled a lever to activate it.
Matt said: "The Prince was lovely and a charming bloke. He took quite an interest in the Tardis's controls and asked a lot of questions about it. He told me and Jenna that he'd been a big fan of the show since he was 15 - which we didn't know.
Also giving the Prince the thumbs up was actor and sound technician Nicholas Briggs, who voices the Daleks. The Lyndhurst-born performer, who began practising Dalek voices at the age of five, said: "The Prince has got a history of performing and has done stuff with The Goon Show previously, so he really stepped up to the plate. Apart from a couple of giggles at the end, he did really good."
The royal couple were also shown around the props department, chatting with set decorator Adrian Anscombe, who handed the Prince a sonic screwdriver. "He got it to work first time, which doesn't usually happen," he said.