The 55-year-old revealed she was upset that she was not consulted about changes being made to the panel show by new ITV daytime boss, Helen Warner.
"Every show needs a shake-up. But the way the show's going, I've felt that my wings have been clipped. I feel the way the show is going is losing the fun of it."
Just this week it was announced that former 'Loose Women' stars Kaye Adams and Coleen Nolan would be rejoining the show next summer.
Since joining 'Loose Women' back in 2002, Denise has appeared as a panellist on 533 shows. She now hoping to focus more on her acting career after starring in the likes of 'Coronation Street' and 'Waterloo Road.