In this one, we see poor Kermit involuntarily swapped with the evil Constantine, and thrown into a Russian gulag. Meanwhile, Constantine, with greasy sidekick Dominic Badguy (Ricky Gervais), works his charms on the other Muppets, including even the ever-loyal Miss Piggy. Will Kermit stay locked away forever, with only a bunch of Russian crims and wild-eyed guard Tina Fey for company?
As always with the Muppets, despite the peril involved, there's plenty of time in the film to break into song and dance, with some of musical supervisor Bret McKenzie's numbers up there with the Muppets' classics.
Before you hear the new stuff, here's a countdown of the most popular Muppets tracks - is your personal favourite in there?
'Muppets Most Wanted' is in UK cinemas from Friday 28 March.
As a special bonus, here’s a clip from the opening song of the 'Muppets Most Wanted' - is this another classic?