The actress - who won the Glamour Icon award - made a joke about her vagina as she collected her gong in front of the celeb-filled audience.
Host Graham Norton had joked earlier in the evening that he couldn't receive an award because he had a 'cock' and US singer Adam Lambert also made a similar comment.
So when Dame Helen took to the stage to collect her gong from actor Ryan Reynolds, she couldn't hold back, asking the guests at the glitzy bash: "If I'm an icon this year, by next year am I kind of de-iconised?
"Anyway I do have a real cock… a psychic cock.
"I do, I mean I love my vagina... but maybe it's that that's got me here, I don't know."
The Oscar-winning actress - who was joined at the ceremony by the likes of Naomi Campbell, Amanda Holden, Alesha Dixon and Claudia Winkleman - also said she loved getting older.
"Forty is good, 50 is great, 60 is fab and 70 is f***king awesome," she said.
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