At least one person is understood to have died in a motorway pile-up involving 30 cars on the M40, on the same day that three men were killed when a coach collided with a stationary car on the northbound M1.
Fire crews, police and air and road ambulances rushed to the M40 between junctions 9 and 10, near Bicester in
Oxfordshire, just before 7.50am after dozens of vehicles were involved in a crash.
A South Central Ambulance Service spokeswoman said they are currently assessing more than 30 patients.
The motorway has been closed northbound between the junctions, while a couple of southbound lanes are shut along the same stretch.
An ambulance spokeswoman said it is too early to know the nature and severity of the injuries suffered by drivers. She said: "It is quite a major collision. We were called at 7.48am to reports of a multiple road traffic collision on the M40, junctions 9 to 10 northbound. I understand that there are about 30 vehicles involved. We are currently assessing in excess of 30 patients.
"We have a lot of resources on the scene - ambulances, our helicopter ambulance, rapid response vehicles, our doctor and our hazardous area response team. Fire and police are also at the scene."
Thames Valley Roads Policing said on Twitter:
A Highways Agency spokesman said all lanes north along the stretch are closed and may remain shut for several hours as police investigate the crash. A couple of lanes south are also closed.
Motorists have also been advised to avoid a stretch of the M1 after a serious crash involving a coach and a car.
Bedfordshire Police said the collision on the northbound carriageway of the motorway between junctions 12 and 13, near Flitwick, at around 6.45am had resulted in a number of serious injuries.
In a statement, the force said: "The northbound carriageway only has been closed for a full collision investigation and diversions are being established. Motorists are advised that these diversions are likely to be in place for most of the day."