Posting a creepy teaser clip to Twitter, Gaga simply said: "Make your reservation now. #GagaAHSHotel"
The singer, real name Stefani Joanne Angelina Germanotta, has had small acting roles in the past but this is her first time starring in a big TV show.
Gaga stunned at the Oscars with her tribute to Dame Julie Andrews, despite rocking up on the red carpet wearing rubber gloves.
Production for 'American Horror Story' Season 5 is scheduled to begin in July and the series will air in October. Gaga's role has not yet been revealed, but director Ryan Murphy has said they left clues about the fifth season in the fourth season.
Murphy and Gaga previously worked together when he used the singer's tracks on "Glee." Gaga has previously appeared in Robert Rodriguez’s "Machete Kills" and had a cameo in his film, "Sin City: A Dame to Kill For."