The TV presenter and her husband Dan Baldwin already have three children together - Harry, six, Belle, four, and 11-month-old Chester.
But it seems there won't be a fourth any time soon.
She told The Sun: "We keep having babies. But I am done now. I am not going anywhere."
The mum-of-three also spoke about how she feels when she's not working alongside her best pal and Celebrity Juice partner-in-crime Fearne Cotton.
Cotton is currently on maternity leave having recently given birth to her daughter Honey Krissy.
Willoughby said: "I miss Fearne. She is a huge part of the show."
Willoughby added that returning from maternity leave was "slightly scary" because of all the changes that happened while she was away from work.
She missed a whole series of Celebrity Juice when she gave birth to Chester and was away from This Morning for a year.
She added: "It was a big decision but it was the quickest year of my life."
Willoughby returned to This Morning alongside Phillip Schofield at the beginning of September.