Rose was best known for her portrayal of Legless Suzi in the fourth series of ‘American Horror Story’, which was subtitled ‘Freak Show’.
Her death was confirmed in a statement on the official ‘AHS’ Facebook page, which read: “We are saddened to learn of the passing of Rose Siggins. She was beloved by everyone in the ‘AHS’ family.
“She was a kind person, a loving mother and a very talented actor. Our thoughts and prayers are with her family and friends at this time.”
In addition to her acting role in ‘American Horror Story’, Rose made several appearances in documentaries to discuss her medical condition.
She was born with sacral agenesis, a rare genetic disorder which causes abnormal fetal development in the lower spine, meaning she had to have her legs amputated at the age of two.
Rose is survived by her husband, and their two children, Luke and Shelby Cecilia.
Her agent, James Mullen, has set up a page on GoFundMe, to encourage fans of the show to donate money, to cover "final expenses and the continuing support of her children".
Several of her ‘AHS’ co-stars have also paid their respects on Twitter, also urging their followers to donate to the GoFundMe page.
The AHS family lost one of our own... Rose Siggins was an absolute light... I will never forget your laugh or your beautiful eyes.— Sarah Paulson (@MsSarahPaulson) December 12, 2015
Today we mourn Rose Siggins who died today. Please consider helping the two children she leaves behind. https://t.co/dCdYjVjuRv— Denis O'Hare (@denisohare) December 12, 2015
So sorry to hear of the passing of Rose Siggins. I pray for her children. Please donate if you can. https://t.co/S9g3zpiRle— Gabourey Sidibe (@GabbySidibe) December 12, 2015
The horror story family lost one of its own today. You were a light, Rose, and you will be missed.December 13, 2015
Rose’s death is the second loss for the ‘AHS’ cast this year, after Ben Woolf - who starred in two series of the cult series - died in February, at the age of 34.
Ben - who starred in both ‘American Horror Story: Freak Show’ and ‘American Horror Story: Asylum’ died in hospital, after sustaining a head injury when he was hit by a car’s side-view mirror.