Deputy President Cyril Ramaphosa will face questions on the minimum wage and the relationship between the legislature and the executive in the National Assembly on Wednesday.
The deputy president will be answering oral questions for the last time this year.
He will also face questions on government's plans to curb the growth of HIV/Aids in adolescent girls and young women.
Both African Christian Democratic Party leader Kenneth Meshoe and United Democratic Movement president Bantu Holomisa will ask for more details on the R3,500 proposed minimum wage.
"Whether, with reference to the different levels of inequality and affordability in the country, the government has taken into consideration to determine the national minimum wage in accordance with a formula that will take cognisance of whether the employer is a corporate entity or private person," Meshoe asks.
Holomisa wants to know if the policy will cover allegedly exploited foreign nationals working in South Africa.
"If not, what is the plan to avoid loss of employment by South African citizens in favour of foreign nationals."
Democratic Alliance leader Mmusi Maimane wants to know if Ramaphosa has managed to build a stronger relationship between the executive and legislature "and encourage members of the executive to respond promptly to matters raised in Parliament during his tenure as the leader of government business in the Fifth Parliament, in order to strengthen Parliament's oversight of the exercise of national executive authority".