Alcoholism Could Be In Your Genes, Not Your Brain | HuffPost

But there is no single 'alcoholism' gene.

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Reporter at HuffPost UK

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New evidence furthers the claim that alcoholism is determined by your genes, and increases the likelihood that in the future we will be able to identify potential candidates likely to suffer.

Researchers at Indiana University School of Medicine have identified hundreds of genes and genetic codes in rats that appear to play a role in increasing the desire to drink alcohol.

Sally Anscombe via Getty Images

In the trials rats were carefully bred to either drink large amounts of alcohol or to reject it (mimicking all criteria of human alcoholism).

By breeding these animals specifically for these experiments, scientists were able to avoid issues that have plagued other alcoholism studies.

These issues included the inability to account for all family history of drinking and non-genetic economic; social and cultural factors that lead to heavy drinking.

After the rats had been bred, they were subject to genome analysis that found the drinking and non-drinking groups of rats had key regions of genetic code that differed from each other.

These were large segments of code, rather than any particular one “alcoholism” gene.

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Lead researcher William Muir, said: “This research highlights that alcoholism in rats has a strong genetic component and is influenced by many hundreds of genes, each with small effects.

“There is no single gene responsible for alcoholism. However, critical regulatory pathways involving several of the genes discovered were found”.

These findings, published in the PLOS Genetics journal, suggest that there are potential pharmalogical solutions to alcoholism in humans in the future.

And medical professionals will be able to accurately predict those at high risk of becoming alcoholics.

Please drink responsibly. For the facts, visit drinkaware.co.uk.

Signs Of Alcoholism

Abuse: Not Meeting Responsibilities(01 of20)

Abuse, the regular use of a substance that leads to serious psychological and/or physical disability, is shown by one or more of these symptoms during the same year:Repeated substance use to the point of not being able to meet responsibilities -- not performing well at work, being suspended from school, being repeatedly late or absent from required duties, or neglecting household tasks. (credit:Shutterstock)

Abuse: Involving Risk(02 of20)

Abuse, the regular use of a substance that leads to serious psychological and/or physical disability, is shown by one or more of these symptoms during the same year:Repeated substance use when there is risk involved, like operating equipment or driving a car while under the influence. (credit:Shutterstock)

Abuse: Difficulties With The Law(03 of20)

Abuse, the regular use of a substance that leads to serious psychological and/or physical disability, is shown by one or more of these symptoms during the same year:Repeated difficulties with the law related to substance use -- being arrested for physical aggression or drunk driving, for instance. (credit:Shutterstock)

Abuse: Personal Or Social Difficulties(04 of20)

Abuse, the regular use of a substance that leads to serious psychological and/or physical disability, is shown by one or more of these symptoms during the same year:Insisting on using the substance regardless of continued or repeated personal or social difficulties because of it, verbal or physical aggression with a loved one, or frequent arguments about the substance use. (credit:Shutterstock)

Dependence: Needing Great Amounts(05 of20)

Symptoms of alcohol dependence, a physical need to drink, are identified as three or more of the following within the same year:Needing greater amounts of alcohol to satisfy cravings. (credit:Shutterstock)

Dependence: An Inability To Reduce Use(06 of20)

Symptoms of alcohol dependence, a physical need to drink, are identified as three or more of the following within the same year:Using the substance longer than planned or more frequently and in greater amounts.An inability to reduce use, despite a sincere wish to do so. (credit:Shutterstock)

Dependence: Going Through Withdrawal(07 of20)

Symptoms of alcohol dependence, a physical need to drink, are identified as three or more of the following within the same year:Going through withdrawal when not using alcohol, with symptoms such as tremors, restlessness, and agitation. (credit:Shutterstock)

Dependence: Avoiding Withdrawal(08 of20)

Symptoms of alcohol dependence, a physical need to drink, are identified as three or more of the following within the same year:Taking a substance or a similar one to avoid the effects of withdrawal. (credit:Shutterstock)

Dependence: Spending Time On Alcohol(09 of20)

Symptoms of alcohol dependence, a physical need to drink, are identified as three or more of the following within the same year:Spending a significant amount of time trying to acquire the substance.Spending less time at work or on other activities because of substance use; a person may completely abandon previously enjoyable activities. (credit:Shutterstock)

Dependence: Drinking In The Face Of Difficulty(10 of20)

Symptoms of alcohol dependence, a physical need to drink, are identified as three or more of the following within the same year:Continuing to drink despite being aware that alcohol is causing psychological or physical difficulties. (credit:Shutterstock)

Addiction: Saying Inappropriate Things(11 of20)

Stephen Gilman, MD, an addiction specialist in New York City, helps determine the severity of alcohol addiction by asking the following questions:Does he/she frequently say inappropriate things? (credit:Shutterstock)

Addiction: Slurred Speech(12 of20)

Stephen Gilman, MD, an addiction specialist in New York City, helps determine the severity of alcohol addiction by asking the following questions:Does his/her speech slurred? (credit:Shutterstock)

Addiction: Missing Work(13 of20)

Stephen Gilman, MD, an addiction specialist in New York City, helps determine the severity of alcohol addiction by asking the following questions:Does he/she miss work? (credit:Shutterstock)

Addiction: Off Balance(14 of20)

Stephen Gilman, MD, an addiction specialist in New York City, helps determine the severity of alcohol addiction by asking the following questions:Is his/her balance off when they walk? (credit:Shutterstock)

Addiction: Trouble With The Law(15 of20)

Stephen Gilman, MD, an addiction specialist in New York City, helps determine the severity of alcohol addiction by asking the following questions:Has he/she gotten in trouble with the law, for example, with drinking and driving? (credit:Shutterstock)

Addiction: Health Problems(16 of20)

Stephen Gilman, MD, an addiction specialist in New York City, helps determine the severity of alcohol addiction by asking the following questions:Is he having health issues related to alcohol addiction, such as heartburn, liver problems, high blood pressure, or insomnia? (credit:Shutterstock)

Question To Ask: Should I Cut Down?(17 of20)

Take the CAGE questionnaire -- if the answer to two or more of the four CAGE questions is yes, it is likely you have a problem.C stands for cut-down: Do you ever feel that you should cut down on your drinking? (credit:Shutterstock)

Question To Ask: People Getting Annoyed?(18 of20)

Take the CAGE questionnaire -- if the answer to two or more of the four CAGE questions is yes, it is likely you have a problem.A stands for annoyed: Have people annoyed you by criticizing your drinking? (credit:Shutterstock)

Question To Ask: Ever Felt Guilty?(19 of20)

Take the CAGE questionnaire -- if the answer to two or more of the four CAGE questions is yes, it is likely you have a problem.G stands for guilty: Have you ever felt guilty about your drinking? (credit:Shutterstock)

Question To Ask: Drinking To 'Recover'?(20 of20)

Take the CAGE questionnaire -- if the answer to two or more of the four CAGE questions is yes, it is likely you have a problem.E stands for eye-opener: Have you ever had to drink as soon as you wake up to steady your nerves or get over a hangover? (credit:Shutterstock)

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