No sooner had the Prime Suspect star been welcomed to the show by Alex and co-host Matt Baker, when things took a decidedly awkward turn.
Referencing a video compilation of Helen’s many roles, Alex - who is standing in for regular host Alex Jones who is on maternity leave - commented that she had played a lot of “feisty” characters.
“Well, you know, I have played housekeepers as well, and I’m playing a cleaner in my next film,” Helen explained. “I hope there’s a bit of variety there.”
The obviously riled actress then added: “I have to say I don’t like the word ‘feisty’. I don’t know why.
“I think it’s because it’s always related to women. They never say ’a feisty man… a kid, maybe. But I find it slightly insulting, I don’t know why. I want to find another word.”
She then told Alex: “See, I was being the boss there, wasn’t I?”
This isn’t the first time a guest presenter on the show has upset a guest.
The Circle host was there to chat about hosting that year’s Brit Awards, but when she was in the middle of a story, she was cut off by Angela mid-sentence.
After Angela asked Emma what her favourite sweets were, she started to tell a personal story about her grandad.
She told hosts Ore Oduba and Angela: “Well one of my all time favourites – because my grandad always had a jar of them in his house and I would literally eat the whole bowl…”
But before she could finish the sentence, Angela then interjected and said: “We’ll come back to that.”
Cue a look of disbelief on Emma’s face.
Watch the full interview with Reese on The Graham Norton Show, BBC One, Friday 1 November at 10.35pm.