His knuckle tattoo, of Heard's nickname 'Slim', has now been changed to say 'Scum' - with the 'l' and 'i' being redrawn as a "c" and "u", respectively.
This wasn't the only inking of Depp's bearing Heard's nickname, he also has the phrase "Come with me... Slim" on his right elbow, and a portrait of her on his arm - which he has since covered up according to photos on TMZ.
Depp's tattoo on 23 May 2016.
The tattoo on 1 July 2016.
Heard's nickname is reported to be a reference to actress Lauren Bacall, known for playing Slim against Humphrey Bogart's Steve in the 1944 film 'To Have and Have Not'.
In a 2011 interview, promoting their film 'The Rum Diary', Depp told USA Today: "When I first saw Amber, it was like seeing an old-time movie star. It was like I was seeing Lauren Bacall."
This isn't the first time Depp has altered a tattoo after a break up - in 1994 he changed a tattoo dedicated to ex-girlfriend Winona Ryder which read 'Winona forever' to say 'Wino forever'.