"I want to address what is one of the most thoughtless, insensitive, and ignorant things I’ve ever done,” she wrote on Instagram.
“Mr. Depp has no personal or professional relationship with Ms. Ortega whatsoever,” his rep said.
The Wednesday actor responded to the claims on her Instagram story.
The docuseries Depp v. Heard is slated to hit the streaming service next month.
Meanwhile, Mary's co-star Jane Fonda also acknowledged getting hot and bothered with someone on camera.
The Aquaman actor moved abroad after a highly publicised defamation trial with ex-husband Johnny Depp.
Johnny Depp's film Jeanne du Barry opened the 2023 Cannes Film Festival.
The Aquaman star wrote on Instagram that she'd made the "very difficult decision to settle the defamation case brought against me by my ex-husband".
Who said romance was dead?