Tuesday's exam, which covered the study of living organisms, apparently asked: "What is meant by the term independent business?"
The unexpected question, which related to a drugs trial company, caused a flurry of anger.
And once outside of exam conditions, pupils quickly vandalised the 'independent business' Wikipedia page...
10 best edits to the 'independent business' Wikipedia page
According to the unedited Wiki, an 'independent business' is one free from outside control.
Yet there were other controversies in the exam - including problematic assumptions about the drinking habits of 15-year-olds.
Lorna Armstrong, a student from Newcastle who began the petition, wrote: "I believe that AQA should issue an apology for including this question".
AQA told The Huffington Post UK it has "no problem" with the questions on Tuesday's exam.
A spokesperson added: "Exams aren't meant to be easy and students are obviously going to tweet about that, but there was nothing wrong with this paper. We wish everyone the best of luck with the rest of their exams."