Team GB will aim to get back into the winning habit after a rare gold medal-free day.
Among the main contenders for a podium place today will be Nicola Adams as she competes in a historic first women's Olympic boxing final.
The flyweight will realise her 17-year dream as she takes on China's Ren Cancan at the Excel Centre in London.
Great Britain's Nicola Adams competes against India's Chungneijang Mery Kom Hmangte during the Women's Boxing Fly Semi Final at the ExCel centre
It will be a key moment for women's boxing, which is part of the Games for the first time this year.
"I've been training for this moment since I was 12 years old and to think it is finally here is just incredible," the 29-year-old, from Leeds, said.
After a rush of medal wins in recent days, Team GB experienced a lean day on Wednesday by their own high standards.
Team GB women's hopes of a place in the Olympic hockey final against Holland were dashed when they lost 2-1 to Argentina.
They will now play New Zealand in a battle for a bronze medal.
While they remain in an impressive third place with 22 golds, there was disappointment for showjumper Nick Skelton, who missed out on any medals in the individual competition.
The equestrian arena will be the centre of attention once more as members of Britain's successful dressage team go for individual gold.
In Hyde Park, Keri-Anne Payne hopes for a medal in the 10km outdoor swim.
Luke Patience and Stuart Bithell are assured of at least a silver medal in the men's 470 class sailing at Weymouth, while Hannah Mills and Sasia Clark will go for gold in the women's event.
A highlight of the day will come as Usain Bolt takes to the track in the 200m men's final at the Olympic Stadium. Bolt sealed his place in Olympic history on Sunday as he became only the second man to defend the 100m title.
The Jamaican clocked a new Games best of 9.63 seconds on his way to gold.
Great Britain's Lawrence Clarke sits on the track after taking fourth place in the Men's 110m Hurdles final
Meanwhile Britain's Lawrence Clarke, who was educated at Eton and is a distant relation of former US president Theodore Roosevelt, last night admitted he was stunned by his "amazing journey" after finishing fourth in the 110 metre hurdles final.
Clarke, nicknamed "toff of the track" due to his privileged background, set a personal best of 13.31 seconds to reach the final as the eighth fastest qualifier.
And the 22-year-old returned to the track two hours later to finish just outside the medals.