Britain's drug policies are failing, Deputy Prime Minister Nick Clegg has said, in direct opposition to David Cameron who ruled out a review into the government's approach earlier this week.
The leader of the Liberal Democrats called on David Cameron to show courage in waging a war against drugs, calling for a reform of drugs laws.
In an interview with the the Sun, Mr Clegg said: "If you were waging any other war where you have 2,000 fatalities a year, your enemies are making billions in profit, constantly throwing new weapons at you and targeting more young people, you'd have to say you are losing and it's time to do something different.
"I'm anti-drugs - it's for that reason I'm pro-reform."
He insisted he is not in favour of full legalisation of drugs but thinks targeting dealers and traffickers, while decriminalising possession, might be a solution.
The Commons Home Affairs Committee found the government's drugs policies to be failing in a report published on Monday, and recommended a royal commission to look at alternatives.
He told the Sun he will include a "clear commitment" to a royal commission on drugs in his party's 2015 manifesto.
He added: "I told the Prime minister that this was a missed opportunity. He knows my views on this. He and I don't agree on this."
Clegg told the BBC there was a "conspiracy of silence" over the failing drugs laws because policies to tackle the problem, such as decriminalisation, are seen as "too controversial."
However despite his disagreement with Cameron, he told the BBC: "I don't see this as a thing between myself and the prime minister. It's what do we as a country believe is the right thing to do."
The Lib Dem leader said he has ordered Home Office minister Jeremy Browne to compile a report on liberal approaches to drugs across the world which have worked, including in Portugal, Amsterdam, Latin America and several US states.