The 51-year-old was spotted wearing a prosthetic nose, bushy eyebrows, a moustache and a couple of warts as he took a break from filming in Los Angeles over the weekend.
Johnny plays an alcoholic former detective called Guy Lapointe in cult director Kevin Smith’s horror-comedy.
The movie is a bit of a family affair with the actor’s 15-year-old daughter Lily-Rose Depp also landing herself a role - the first time the pair have shared the screen.
And Johnny isn’t the only actor on the film who is sporting a brand new look.
Former child star Haley Joel Osment, who shot to fame in ‘The Sixth Sense’, is all grown up and looking rather different these days.
The actor, now 26-years-old, plays a scary looking Nazi in the film.
Speaking on The Today Show about his new look, he said: "Luckily with the internet today, people can quickly see why I was dressed as a Nazi.
"So yeah, that was kind of funny."
The film is due to hit cinemas later this year.