LIFESTYLE
18/03/2015 09:44 GMT | Updated 18/03/2015 09:59 GMT

Hangover-Free Wine Could Soon Be A Reality *Takes Giant Swig From Bottle*

If you love wine, but hate hangovers then prepare to get the next round in... because hangover-free wine could soon be on the menu.

Scientists believe they may have discovered the key to reducing that awful morning-after feeling, by removing toxic byproducts found in fermented goods, such as beer and wine, using a "genome knife".

And the breakthrough may not just ease hangovers, but could boost the health benefits of wine and even make it smoother to the taste.

Got your attention? Thought so.

hangover

"Fermented foods--such as beer, wine, and bread--are made with polyploid strains of yeast, which means they contain multiple copies of genes in the genome," explains Yong-Su Jin, a University of Illinois associate professor of microbial genomics and principal investigator in the Energy Biosciences Institute, according to Eureka Alert.

"Until now, it's been very difficult to do genetic engineering in polyploid strains because if you altered a gene in one copy of the genome, an unaltered copy would correct the one that had been changed."

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The possibilities for improved nutritive value in foods are staggering, he said. "Wine, for instance, contains the healthful component resveratrol. With engineered yeast, we could increase the amount of resveratrol in a variety of wine by 10 times or more.

"But we could also add metabolic pathways to introduce bioactive compounds from other foods, such as ginseng, into the wine yeast. Or we could put resveratrol-producing pathways into yeast strains used for beer, kefir, cheese, kimchee, or pickles--any food that uses yeast fermentation in its production."

Another benefit is that winemakers can clone the enzyme to enhance malolactic fermentation, a secondary fermentation process that makes wine smooth. Improper malolactic fermentation generates the toxic byproducts that may cause hangover symptoms, he said.

Jin stressed the genome knife's importance as a tool that allows genetic engineers to make these extremely precise mutations.

"Scientists need to create designed mutations to determine the function of specific genes," he explained. "Say we have a yeast that produces a wine with great flavor and we want to know why. We delete one gene, then another, until the distinctive flavor is gone, and we know we've isolated the gene responsible for that characteristic."

The new technology also makes genetically modified organisms less objectionable, he said. "In the past, scientists have had to use antibiotic markers to indicate the spot of genetic alteration in an organism, and many persons objected to their use in foods because of the danger of developing antibiotic resistance. With the genome knife, we can cut the genome very precisely and efficiently so we don't have to use antibiotic markers to confirm a genetic event."

The research was reported in a recent issue of Applied and Environmental Microbiology.