The A38 is closed one way between the B600 near Alfreton and the M1 at junction 28 after a bin lorry fire.
The northbound carriageway between A61 Derby Road/ B6179 Derby Road (Watchorn Island) and M1 J28 (Alfreton/ Mansfield) will remain closed for emergency resurfacing, recovery and structural assessment until midnight at the earliest, Derby Roads Police tweeted.
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The southbound carriageway of the A38 between junction 28 of the M1 and Alfreton is now open.
Schools are being advised parents may be late to collect their children.
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