Complete with a fake belly, a bright red tie, a wig and a lot of fake tan, Streep stepped into the spotlight to sing a rendition of Cole Porter’s Brush Up Your Shakespeare with Christine Baranski.
Meryl has previously shown her skill as an impressionist taking on the roles of Margaret Thatcher and Emmeline Pankhurst, but this may be her most convincing effort to date.
The Oscar winning actress is a firm supporter of Hillary Clinton, so it's no surprise she took this opportunity to poke fun at the Republican candidate.
“You’ll let me know, why all the women say no,” Streep sang to a chorus of laughter as she mocked the presidential hopeful.
The song comes from the musical 'Kiss Me Kate', and is usually sung by a pair of gangsters discussing how reciting lines from Shakespeare can help them pick up women.
We're not sure Streep would be able to woo anyone while wearing the ridiculous outfit, but a few lines from Othello certainly wouldn't hurt.
Praise for Streep's performance is already flooding in on Twitter: