Thousands joined the programme's hashtag to highlight the "right-wing" views of guests on the programme, which included former Sun editor Kelvin McKenzie, Times columnist Camilla Long, Tory Minister Nick Boles, and Ukip's Patrick O'Flynn.
Is this the most right wing #bbcqt panel evah?— Iain Dale (@IainDale) January 14, 2016
Right-wing panel, Left-wing audience. Result. No one to cheer, no one's quite sure who to boo. #bbcqt— Tim Stanley (@timothy_stanley) January 14, 2016
#bbcqt seems to have ditched any attempt at balance with 4 right-wing panellists out of 5 tonight.— david white (@davidwhite020) January 14, 2016
No idea why I do this to myself...tuning into #bbcqt knowing for sure (judging by the panel) that I'm gonna be pissed off in 2.5 minutes...😏— Prossy (@Pkakooza) January 14, 2016
#bbcqt getting the feeling a bucket of valium and a barrel of blue nun wont be enough to soften the right wing tripe on the show tonight— Simon Gibson (@ticketyboo67) January 14, 2016
#bbcqt so a new year for bbcqt immigration watch, shocking panel, 2 murdoch flunkies, a kipper, a tory & a lone voice from the left— Simon Gibson (@ticketyboo67) January 14, 2016
Wirral South Labour MP Alison McGovern also lent her voice to the criticism, advising her followers to complain directly to the BBC.
She used the #jft96 hashtag to highlight The Sun's coverage of the Hillsborough stadium disaster in which 96 Liverpool fans died.
Like McGovern, many were motivated by McKenzie's leadership of The Sun following Hillsborough, which saw the tabloid's coverage of the disaster blame fans.
Some Labour supporters placed the panel in the context of controversy over the BBC's decision to persuade Labour shadow cabinet member Stephen Doughty to resign live on its 'Daily Politics' programme.
Meanwhile, other commentators lamented the panels lack of ethnic diversity.
BBC has an obligation to diversity of:ethnicity;age;ability;region; religion.etc. Head of @BBCScotland agreedJanuary 14, 2016
Previous research conducted by Labour MP David Lammy found that as many as 60% of all Question Time panels over the last parliament lacked any black or minority ethnic voices.
However, those criticising the programme for political bias perhaps have short memories.
BBC panels and audiences have been routinely criticised for being too left wing, with Ukip leader Nigel Farage even deciding to censure an entire audience for bias during a General Election debate last year.
In fact, an analysis by the New Statesman last year found that, at least on a party-by-party basis, that claims of bias didn't really stack up, concluding there was a "slight, slight tilt to the right is barely worth talking about."
The BBC told HuffPost UK: "Question Time hears from a range of voices and usually consists of one senior politician from both the Labour and Conservative party, as well as representatives from other political parties.
"The rest of the panel is made of political commentators, journalists, and other public figures that add a different perspective and represent a range of viewpoints across the series."