Loneliness is literally painful. It activates the same brain areas that alert us to physical pain, making us seek out others and encouraging us to spend time with family and friends. To prevent our brains triggering this feeling, we must understand why it happens and learn to respond to it promptly.
Living with the feeling that your life and existence mean very little to anyone at all can create a dangerous state of mind, only worsened by the idea that the reason for your loneliness is shameful. Those who are estranged are too often reminded of the isolating family myth - that everyone else in society is enjoying a functional and close family experience.
"Hey you. If you've got a problem, do something about it. Don't talk about it. Nobody cares." As a man, I've heard this before. All the time actually, and in several different ways. After a girlfriend cheated on me, when I was shattered and expressed a need to discuss it, a friend told me: "You need to stop talking and thinking about it right now. Nobody cares."