Living with the feeling that your life and existence mean very little to anyone at all can create a dangerous state of mind, only worsened by the idea that the reason for your loneliness is shameful. Those who are estranged are too often reminded of the isolating family myth - that everyone else in society is enjoying a functional and close family experience.
"Hey you. If you've got a problem, do something about it. Don't talk about it. Nobody cares." As a man, I've heard this before. All the time actually, and in several different ways. After a girlfriend cheated on me, when I was shattered and expressed a need to discuss it, a friend told me: "You need to stop talking and thinking about it right now. Nobody cares."