Disgraced former defence secretary Liam Fox is expected to make a personal statement to the Commons after a critical report into his activities with close friend Adam Werritty.
Labour is poised to pile pressure on David Cameron to also make a statement about the affair, claiming there are a raft of questions left unanswered.
The Prime Minister will be braced for opposition MPs to quiz him about the embarrassing revelations over Dr Fox's working relationship with the self-styled adviser.
Sir George Young, Leader of the House, has currently been pencilled in by Downing Street to make a statement on behalf of the Government. But Labour is considering attempting to force the Prime Minister into making the address instead by triggering an urgent question in the House.
That manoeuvre failed on Tuesday after Speaker John Bercow ruled there would be little point debating the report until it had been published but he indicated he would be prepared to grant one on Wednesday.
Cabinet Secretary Sir Gus O'Donnell's report on Tuesday criticised Dr Fox for ignoring the advice of senior officials over his links to Mr Werritty. It also found that by giving his friend access to his diary, Dr Fox created a security risk not only to himself but also to officials travelling with him on overseas visits.
And an "inappropriate and unacceptable" blurring of lines between official and personal relationships risked creating the false impression that Mr Werritty - who met Dr Fox 22 times in the MoD's Whitehall HQ and 18 times on trips abroad, and used business cards describing himself as an adviser to the Defence Secretary - spoke on behalf of the UK Government.
The 10-page report cleared Dr Fox, who resigned as defence secretary on Friday, of making any financial gain from the relationship or of breaching national security. Their relationship "did not impact on UK foreign or security policy", said Sir Gus.
Conservative officials confirmed on Tuesday night that Dr Fox's office had formally requested space in Wednesday's Commons timetable to address MPs and that is expected to be agreed to later.
His speech is expected to "echo" the statement he released on Tuesday night, which said he was "pleased" that the report made clear that allegations of any financial gain or breach of national security had "no basis".