In an exclusive interview with HuffPost UK, Kylie says it would be 'incredible' to make sweet music with Madge.
"Of course! That would be incredible," she told us. "It's like maybe the world would stop mid orbit! Yeah, it would be incredible.
"I don't know if it would ever happen. Maybe it's something that will live in our imagination," she added.
And Madonna isn't the only female singer the 'Voice' star would like to hook up with musically - she also revealed Lady Gaga would be a dream come true too.
"Again, I'd love that to happen," she said. "I don't get to collaborate with many women so it would be amazing.
"But seriously, there are so many people… Frank Ocean. I was listening to him a lot last year and you just think that would be so cool because it would just be so unexpected."