Calvin had been scheduled to open the show on Sunday night, which is being held in his native Scotland, but has had to cancel his DJ set due to what he put down to problems with his heart.
An official statement from the MTV Europe Music Awards explained: “We have really sad news. Calvin Harris has taken ill and will not be able to perform at the show. He sends his sincere apologies. Get well soon, Calvin!”
According to The Mirror, the DJ later took to his Twitter to explain his absence from the ceremony, saying: “No EMAs for me this weekend. Got some heart problems. Heading home to see if it can be fixed [sic]”
Following Calvin’s cancellation, it has now been reported that show bosses are frantically trying to re-organise the ceremony, before it all kicks off in Glasgow on Sunday night.
Nicki Minaj will be taking on presenting duties, while the event will also feature performances from stars including Ariana Grande, Ed Sheeran and U2.
The event will also honour Ozzy Osbourne - who it was announced this week is due to feature in new episodes of ‘The Osbournes’ next year - with the Global Icon award, previously won by Eminem, Whitney Houston and Queen.