Pictures and video on Twitter have shown thick black smoke billowing into the sky and fire crews maintaining the crash site.
The number of passengers onboard is not yet known, although the Spanish Prime Minister says there may have been up to 10 people, although it was later confirmed that six were onboard. Emergency services have located four bodies bodies and two people were seriously injured in the crash.
Spanish Prime Minister Mariano Rajoy said up to 10 crew members were on board the plane, which was undergoing flight trials at the airport. It is not known if any others were injured.
An MoD spokeswoman said: "We are aware of reports that there has been an A400M crash in Seville. As a precaution, the UK's A400M aircraft are temporarily paused."
Airbus Defence and Space said: "We confirm that there has been an accident with an A400M in Sevilla. At this point, we can confirm that the aircraft is MSN23, an aircraft foreseen for the Turkish customer."
All flights inbound for Seville have been diverted to Malaga and Jerez.
The aircraft is a transport plane which normally carries crews of 2-4 people. The wingspan is 42.4 metres with a length of 45 metres.
The Royal Air Force has confirmed that this plane was not an RAF aircraft, but both run by the UK have been grounded as a precautionary measure.
More to follow.