The audience member, who spoke out on BBC 'Question Time', berated energy secretary Amber Rudd for backing a move that will see an average £1,300 cut to the annual income of around 3.2 million families.
"I voted for Conservatives originally, cos I thought you were going to be the better chance for me and my children. You're about to cut tax credits after promising you wouldn't," the aggrieved lady lamented.
"I work bloody hard for my money. To provide for my children to give them everything they've got - and you're going to take it away from me and them.
"I can hardly afford the rent I've got to pay, I can hardly afford the bills I've got to do, and you're going to take more than me."
As Rudd shifted with discomfort, the woman shouted, "shame on you."
Hundreds came out supporting the sentiment, penning heartfelt messages that called on Chancellor George Osborne to back down over the proposals.
There were some who claimed the unnamed woman "deserved" her fate, having voted Conservative in May's general election.
But many more blasted those attacking her for a lack of sympathy.
Thursday night's tax credit tirade also saw journalist Rod Liddle, fresh from penning a column on the 'Great British Bake-Off' that drew praise from the EDL, engaging in a rambunctious scrap with historian Simon Schama on the issue of migration.