Police fired tear gas at English football fans on Wednesday evening and there were reports of scuffles and a "loud bang" on the streets of Lille.
Authorities used batons, pepper spray and tear gas on supporters, according to Sky News.
French officers could be seen clearing the streets.
Other fans could be seen singing about Jamie Vardy, though there appeared to be better behaviour on display (apart from drinks being thrown around).
The Associated Press reported that a group of about 200 English fans had been getting progressively rowdier and noisier, singing songs taunting Russia, when a loud explosion was heard and some bottles were thrown.
Police appeared to make at least one arrest, pinning a man against the ground.
England plays in the nearby city of Lens on Thursday and thousands of their supporters have gathered in Lille.
Meanwhile Russian fans set off a flare after their team scored in their latest Euro 2016 game - despite being warned their team could be thrown out of the tournament if they did so.
After Russia’s Denis Glushakov scored against Slovakia in the 80th minute, a flare was ignited inside the Stade Pierre-Mauroy in Lille.
They went on to lose the match 2-1.
Earlier this week, Uefa handed Russia a suspended disqualification from the tournament and a £119,000 fine following the crowd disturbances at the England versus Russia game in Marseille on Saturday.
A statement from the governing body specifically mentioned the use of fireworks.
On Tuesday French riot police also surrounded a bus of Russian supporters as it left Cannes for Lille. Authorities are said to have drawn up 29 deportation orders and taken fans to the airport.
Uefa handed Russia a suspended disqualificationThe Football Association was warned previously that further disorder could lead to the England team also being expelled from the tournament, even though the FA was not formally charged by the European football governing body.
A huge security operation surrounding England’s next Euro 2016 match has been bolstered, with extra British police deployed to France ahead of the next round of Group B games.
Authorities in England and Russia have appealed for supporters to behave after disorder in Marseille.