During an interview with New York radio station Hot 97, the UK rapper said Meghan was a “lovely woman” and suggested criticism aimed at her is rooted in racism.
His comments came after the Sussexes announced their decision to step down as senior royals, with the aim of becoming financially independent and live part of the year in North America.
Stormzy said: “I ain’t heard her say anything crazy, she just does her thing and they just hate her.
“Someone on Talk Radio the other day, he was like ‘she’s just one of those people that I just look at her and I think…’
“And I was like, na, she’s just black man, get the fuck out of here.”
He added: “If you told someone ‘write a list as to why you hate Meghan Markle’, the list is just rubbish.
“There’s nothing credible to it.”
The Brit Award-winner also revealed he is not “super into the royal family”.
Meanwhile, Naomi Campbell has backed the couple, telling the PA news agency: “I support them whatever.”
The supermodel had previously voiced her support for Meghan’s decision to launch legal action against a national newspaper.
She told the Guardian: “When I heard (she was taking legal action), I was like ‘Bravo. Good for her’.”
The royal couple were the topic of conversation between Piers and Dr Shola Mos-Shogbamimu, who suggested the treatment of Meghan Markle in the media was symptomatic of racism in the UK.
“Where is this racism that you keep talking about?” Piers demanded. “Where are the ghastly tabloids which you say have been driving this racist agenda against a woman who was lauded and welcomed?”
Dr Shola then suggested Piers was asking a deliberately “obtuse” question, pointing out that if he’d watched any of her recent interviews, he’d see that she’d given plenty of examples.
“Let me tell you what’s so offensive about this Piers, especially with you. You are a man, privileged to have power and influence and you are using your platform so irresponsibly to spout out this personal vendetta with nasty and vile comments knowing fully well that your words are containing bigotry, misogyny, sexism and racism.
“You don’t take responsibility for how you have contributed to the so-called royal crisis. So when you ask me where is racism, it is not my job teach you about racism.”