Steve Rotheram urged people to stick to "tier 3" local lockdown as he slammed "shameful" images of partying crowds.
The chancellor unveiled a new scheme on Friday to help workers living under local lockdowns, but leaders say they "cannot accept" the plans.
Chancellor expands job support scheme for firms closed by new coronavirus restrictions, with lockdown changes expected next week.
Economists and industry figures say the "less generous" scheme could bring about "a new wave" of unemployment.
The chancellor has revealed his winter economic plan to replace the coronavirus furlough scheme.
Political as much as economic dangers loomed large for the Treasury.
Rishi Sunak will deliver an emergency economic statement on Thursday following the imposition of new coronavirus restrictions.
Labour highlighted the comparative cost as the chancellor repeatedly refused to increase sick pay.
Everything you need to know about pay, notice period, holiday entitlement and unfair dismissal.
The Labour leader will also warn the PM of the "scarring effect" mass unemployment could have on communities.