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The actor, who recently reprised his role as Robbie Jackson on the BBC One soap, blasted brother Gary’s “lies” and said that karma would get him, following the reports.
Speaking to the Daily Star, Gary claimed that Dean is “sex-mad” and had slept with over 1,000 women, adding that he calls his penis “Wellard”, after his character’s pet dog.
He also claimed that Dean’s hopes of rejoining the ‘EastEnders’ cast on a permanent basis would be thwarted by his wild sex life.
“I think he will go off the rails again. If you work for the BBC you have to represent the company. You are not bigger than the show itself.”
“It will all be taken away from him and it will be because of the sex thing.”
After the report was published, Dean took to Twitter to vent his anger.
"In life we're let down… But you never expect your own flesh and blood to sell lies about you,” he wrote.
"I have no words! I'll let Karma deal with you!"
In life we're let down..But you never expect your own flesh and blood to sell lies about you..I have no words!
I'll let Karma deal with you!— Dean Gaffney (@deangaffney1) September 27, 2015
Dean and Gary have been estranged in recent years, following a fight on Christmas Day in 2004, while Gary claims their relationship has worsened because of the way Dean treats women.
The star revealed his shame of his love-rat reputation earlier this year, insisting he had changed his ways, having cheated on his partner of 22 years, Sarah Burge.
Speaking to The Sun in July, he said: “Women were my drug and now, looking back, I'm ashamed of my past. How many times did it happen? I couldn't put a finger on it.
"Whenever Sarah confronted me about my cheating, I'd just deny, deny, deny. She loved me so much, she wanted to believe me.
"What makes my behaviour even more unforgivable is that Sarah is the nicest woman on the planet. She made allowances for me because we met so young, aged 15.
"She hoped I'd get it all out of my system. But I was selfish and now she has moved on with her life. But I'll always consider her my best friend," he added.