The prestigious award announced its 2015 shortlist on Monday, revealing an eclectic list of politicians, business people, and activists.
Abu Bakr Albaghdadi and Donald Trump
But the award may well become 'People of the Year' as activists involved in the Black Lives Matter campaign are considered for their work campaigning for race equality.
Television star Caitlyn Jenner and Travis Kalanick, the CEO of minicab hailing app Uber, complete the list.
The magazine published its shortlist as Donald Trump, who leads the polls in the race for Republican nomination for president, announced his policy of preventing all Muslims from travelling to the United States.
Activists from Black Lives Matter campaign at a rally
Nonetheless, the award aims to recognise those who have been most influential, though perhaps not the most popular.
Abu Bakr Al-Baghdadi, the leader of Isis, is considered for the award on account of his role in inspiring followers "to both fight in his self-declared caliphate of Iraq and Syria, and also stage attacks in countries like Tunisia and France."
The winner of the award will adorn the special issue of TIME magazine, and will be announced on Wednesday morning in the U.S.