While he perhaps does not receive the acclaim some feel he deserves, Blind is one of United's most important players at present and with the hectic festive period looming, the midfielder's absence is likely to seriously dent their chances of returning to Europe's elite competition.
Out of contract in the summer and therefore likely to be available on cut-price deals in January, here's a look at six short term options for van Gaal and United - any of which could be valuable assets over the next couple of years.
Football has become a massive global brand over time. With the almost daily coverage of Europe's top leagues beamed around the world for multi-million pound TV deals, from here in the UK all the way to the United States, the UAE, China, and South Korea...
Four goals for Brazil at the 2014 World Cup convinced the world that Neymar can carry the goalscoring burden for his country and it's evident that his absence in the eventual 7-1 defeat to Germany affected his teammates. The pressure that comes with shouldering such a responsibility is enough to see any player crumble, but Neymar did so effortlessly...
Dyche has ample time now to work out a system that will help his side overcome Stoke later this month as they aim to climb up the table. However, unless Burnley improve after the international break, the win over Hull may be nothing more than a false dawn in what could be a long season for the Clarets.
If he can prolong the level of consistency he has shown over the last 4 games for the foreseeable future, QPR have a much better chance of staving off relegation. From a personal perspective, though, Austin will look to maintain his good form in order to force his way into Hodgson's next England squad, having arguably been harshly overlooked this time around.
Manchester City won their second Premier League crown last term, but are already playing catchup in this season's title race after a string of poor results over the first three months of the campaign. But the current City team isn't alone in melting under the pressure when it comes to defending the title, with several spectacular examples over the years.
He shouldn't go. It's as simple as that. The run of embarrassing defeats and general disappointing football has endured through three managers now, and adding a fourth name to that list will do nothing at all, except perhaps lengthen the process.
Moving outside the comfort zone of the Premier League is a bold step for the Scot but if he can make an impression on La Liga, then he will prove to all of his doubters that he still has what it takes to manage at the highest level. Real Sociedad may just be the perfect place for Moyes...
Currently, there's a widespread feeling of confusion at Filbert Way. After an impressive haul of eight points against Arsenal, Everton, Chelsea, Stoke and Manchester United, the Foxes have failed to pick up more than a solitary point against less fancied outfits Crystal Palace, Burnley, Newcastle, Swansea and West Brom - as well as high-flying Southampton. Begging the question; what on earth has happened to Leicester City?
While he will enjoy that much more than those previously seen at the ground, it speaks volumes that even positive signs have negative connotations and are displayed almost in jest. His Newcastle team have what it takes to extend their run of form, though it is unlikely to mean much more in the way of support and backing for Pardew.
Raiding the Eredivisie for talent is a risk - see the likes of Afonso Alves and Mateja Kezman - but is one that can pay off. With Saints flying high in England's top tier, Tadic can be considered one of the signings of the summer and with winnable fixtures like Leicester and Aston Villa approaching, there is no reason why he cannot continue his fine form.
Unfortunately for Liverpool, Rodgers' failings in the transfer market aren't exclusive to this past summer and are evident throughout his entire Anfield reign. His very first signings were Joe Allen and Fabio Borini, players he had successfully worked with before.
A number of summer signings have come into their respective clubs and flourished in the Premier League. However, that has not been the case for every new player and some have failed to find their feet or live up to expectations.
The line from British commentators and reporters has long been the same - the Premier League is the best league in the world. By a mile. No debate. But even if that was once true, it's abundantly clear that it's now a delusion, a line repeated out of familiarity rather than any sort of evidence.
Like the current extended summer we've experienced in the UK, the fate of Premier League managers appears to be undergoing a similar process. Any day now the temperature is sure to drop ten degrees and the first managerial departure is expected to arrive with it.