The Prime Minister told the Evening Standard Diary: “I have to say that after the events I have been facing over the last few days, assassination would be a welcome release.”
Cameron was speaking as he hosted a book launch at Downing Street for BBC journalist Andrew Marr's political thriller Head of State, which features the assassination of a prime minister in its plot.
In a bid to undermine the potential motivation for wavering Scots to back independence, the Tory leader has insisted that a Yes vote would not lead to his resignation.
"My name is not on the ballot paper," he told reporters. "What's on the ballot paper is 'does Scotland want to stay in the United Kingdom, or does Scotland want to separate itself from the United Kingdom?'. That's the only question that will be decided on Thursday night. The question about my future will be decided at the British general election coming soon."