The former Friends star was the first celebrity guest when the show launched in 2003.
The Kelly Clarkson Show will replace Ellen beginning in autumn 2022, NBC announced.
The US talk show host has refuted claims she decided to end her talk show over allegations of workplace misconduct.
After *that* very awkward interview in 2019, fans can't help but wonder if it helped cause the show's demise.
The Ellen DeGeneres Show will finish in 2022, which the host says is happening because she needs "something new to challenge me".
The talk show host detailed having three of the drinks the night her wife needed to be rushed to the hospital.
Staff members working on the US talk show alleged last year that they faced racism, sexual harassment and other workplace misconduct.
'I Only Licked Three Door Handles': Ellen DeGeneres Recalling Her Covid Experience Is Typically Ellen
The US presenter and comedian has returned to the Ellen DeGeneres Show after testing positive for coronavirus last month.
In the wake of her diagnosis, Ellen said she was halting production of her daytime talk show until early 2021.
The youngest Kardashian sister told Ellen DeGeneres that she doesn't want haters to "overshadow all the greatness" of the private-island bash.