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The Premier League belatedly kicked into life with a couple of barnstorming encounters and a shock result at Anfield, as previously unbeaten Liverpool lost to Southampton.
Dejan Lovren's header was enough to give Mauricio Pochettino another outstanding win as Saints boss. Southampton defeated the Reds 3-1 in March.
At Upton Park, two Leighton Baines free-kicks drew Everton level after West Ham took the lead twice through Ravel Morrison and Mark Noble, who was later sent off. Debutant Romelu Lukaku struck the winner, with the Toffees the only remaining unbeaten side in the Premier League.
Premier League pictures
FBL-ENG-PR-LIVERPOOL-SOUTHAMPTON(01 of50)
Liverpool's English midfielder Steven Gerrard takes a free kick during the English Premier League football match between Liverpool and Southampton at Anfield stadium in Liverpool, northwest England, on September 21, 2013. AFP PHOTO / PAUL ELLIS RESTRICTED TO EDITORIAL USE. No use with unauthorized audio, video, data, fixture lists, club/league logos or live services. Online in-match use limited to 45 images, no video emulation. No use in betting, games or single club/league/player publications. (Photo credit should read PAUL ELLIS/AFP/Getty Images) (credit:Getty Images)
Liverpool v Southampton - Premier League(02 of50)
LIVERPOOL, ENGLAND - SEPTEMBER 21: Victor Moses of Liverpool in action with Jose Fonte of Southampton during the Barclays Premier League match between Liverpool and Southampton at Anfield on September 21, 2013 in Liverpool, England. (Photo by Clive Brunskill/Getty Images) (credit:Getty Images)
FBL-ENG-PR-LIVERPOOL-SOUTHAMPTON(03 of50)
Liverpool's Uruguayan striker Luis Suarez watches from a hospitality box during the English Premier League football match between Liverpool and Southampton at Anfield stadium in Liverpool, northwest England, on September 21, 2013. AFP PHOTO / PAUL ELLIS RESTRICTED TO EDITORIAL USE. No use with unauthorized audio, video, data, fixture lists, club/league logos or live services. Online in-match use limited to 45 images, no video emulation. No use in betting, games or single club/league/player publications. (Photo credit should read PAUL ELLIS/AFP/Getty Images) (credit:Getty Images)
FBL-ENG-PR-LIVERPOOL-SOUTHAMPTON(04 of50)
Southampton's Kenyan midfielder Victor Wanyama (R) challenges Liverpool's Spanish striker Lago Aspas (R) during the English Premier League football match between Liverpool and Southampton at Anfield stadium in Liverpool, northwest England, on September 21, 2013. AFP PHOTO / PAUL ELLIS RESTRICTED TO EDITORIAL USE. No use with unauthorized audio, video, data, fixture lists, club/league logos or live services. Online in-match use limited to 45 images, no video emulation. No use in betting, games or single club/league/player publications. (Photo credit should read PAUL ELLIS/AFP/Getty Images) (credit:Getty Images)
Soccer - Barclays Premier League - Liverpool v Southampton - Anfield(05 of50)
Liverpool Manager Brendan Rodgers during the Barclays Premier League match at Anfield, Liverpool. (credit:PA)
Soccer - Barclays Premier League - Liverpool v Southampton - Anfield(06 of50)
Southampton's Dejan Lovren celebrates his goal during the Barclays Premier League match at Anfield, Liverpool. (credit:PA)
Soccer - Barclays Premier League - Liverpool v Southampton - Anfield(07 of50)
Southampton's Dejan Lovren celebrates his goal during the Barclays Premier League match at Anfield, Liverpool. (credit:PA)
Soccer - Barclays Premier League - Liverpool v Southampton - Anfield(08 of50)
Southampton's Dejan Lovren celebrates his goal during the Barclays Premier League match at Anfield, Liverpool. (credit:PA)
Soccer - Barclays Premier League - Liverpool v Southampton - Anfield(09 of50)
Southampton's Rickie Lambert misses a shot at goal during the Barclays Premier League match at Anfield, Liverpool. (credit:PA)
Soccer - Barclays Premier League - Liverpool v Southampton - Anfield(10 of50)
Liverpool's Steven Gerrard rues a missed chance as Southampton's Arthur Boruc saves his free kick during the Barclays Premier League match at Anfield, Liverpool. (credit:PA)
Soccer - Barclays Premier League - Norwich City v Aston Villa - Carrow Road(11 of50)
Aston Villa manager Paul Lambert (right) with the injured Christian Benteke on the touchline (credit:PA)
Soccer - Barclays Premier League - Norwich City v Aston Villa - Carrow Road(12 of50)
Aston Villa's Karim El Ahmadi (left) and Norwich City's Nathan Redmond (right) battle for the ball (credit:PA)
Soccer - Barclays Premier League - Norwich City v Aston Villa - Carrow Road(13 of50)
Detail view of a Norwich City player wearing rainbow laces in their boots as part of an anti-homophobia campaign (credit:PA)
Soccer - Barclays Premier League - Norwich City v Aston Villa - Carrow Road(14 of50)
A television cameraman follows Aston Villa manager Paul Lambert (centre) and goalkeeper Bradley Guzan (right) as they celebrate after the final whistle (credit:PA)
Soccer - Barclays Premier League - Norwich City v Aston Villa - Carrow Road(15 of50)
Aston Villa goalkeeper Brad Guzan celebrates after the final whistle (credit:PA)
Soccer - Barclays Premier League - Norwich City v Aston Villa - Carrow Road(16 of50)
Aston Villa manager Paul Lambert (centre) celebrates after the final whistle with Karim El Ahmadi (left) and Andreas Weimann (credit:PA)
Soccer - Barclays Premier League - Norwich City v Aston Villa - Carrow Road(17 of50)
Aston Villa's Libor Kozak (centre) celebrates after scoring his team's opening goal during the Barclays Premier League match at Carrow Road, Norwich. (credit:PA)
Soccer - Barclays Premier League - Norwich City v Aston Villa - Carrow Road(18 of50)
Norwich City's Robert Snodgrass (7) has his penalty saved by Aston Villa goalkeeper Bradley Guzan (not in picture) (credit:PA)
Soccer - Barclays Premier League - Norwich City v Aston Villa - Carrow Road(19 of50)
Norwich City's Robert Snodgrass (7) has his penalty saved by Aston Villa goalkeeper Bradley Guzan (credit:PA)
Soccer - Barclays Premier League - Norwich City v Aston Villa - Carrow Road(20 of50)
Norwich City's Leroy Fer (left) and Aston Villa's Karim El Ahmadi (right) battle for the ball (credit:PA)
Soccer - Barclays Premier League - Newcastle United v Hull City Tigers - St James' Park(21 of50)
Newcastle United's Loic Remy rues a missed chance during the Barclays Premier League match at St James' Park, Newcastle. (credit:PA)
Soccer - Barclays Premier League - Newcastle United v Hull City Tigers - St James' Park(22 of50)
Hull City's Ahmed Elmohamady and Tom Huddlestone celebrate their win after the Barclays Premier League match at St James' Park, Newcastle. (credit:PA)
Soccer - Barclays Premier League - Newcastle United v Hull City - St James' Park(23 of50)
Hull City's Sone Aluko (right) celebrates scoring his sides third goal of the game (credit:PA)
Soccer - Barclays Premier League - Newcastle United v Hull City Tigers - St James' Park(24 of50)
Hull City Sone Aluko scores his sides third goal at the Barclays Premier League match at St James' Park, Newcastle. (credit:PA)
Soccer - Barclays Premier League - Newcastle United v Hull City Tigers - St James' Park(25 of50)
Newcastle United manager Alan Pardew with Yohan Cabaye at the Barclays Premier League match at St James' Park, Newcastle. (credit:PA)
Soccer - Barclays Premier League - Newcastle United v Hull City Tigers - St James' Park(26 of50)
Hull City's Stephen Quinn (left) and Newcastle United's Loic Remy battle for the ball during the Barclays Premier League match at St James' Park, Newcastle. (credit:PA)
Soccer - Barclays Premier League - Newcastle United v Hull City Tigers - St James' Park(27 of50)
Hull City's Ahmed Elmohamady celebrates scoring his sides second goal during the Barclays Premier League match at St James' Park, Newcastle. (credit:PA)
Soccer - Barclays Premier League - Newcastle United v Hull City Tigers - St James' Park(28 of50)
Newcastle United keeper Tim Krul is beaten as Hull City's Ahmed Elmohamady (not in picture) scores during the Barclays Premier League match at St James' Park, Newcastle. (credit:PA)
Soccer - Barclays Premier League - Newcastle United v Hull City - St James' Park(29 of50)
Newcastle United's Loic Remy celebrates scoring his sides second goal of the game (credit:PA)
Soccer - Barclays Premier League - Newcastle United v Hull City Tigers - St James' Park(30 of50)
Hull city tigers players, Stephen Quinn, left, Liam Rosenior, middle & Robbie Brady Right celebrate Hull opening goal at the Barclays Premier League match at St James' Park, Newcastle. (credit:PA)
Soccer - Barclays Premier League - West Bromwich Albion v Sunderland - The Hawthorns(31 of50)
Sunderland manager Paulo Di Cannio watches his team against West Bromwich Albion, during the Barclays Premier League match at The Hawthorns, West Bromwich. (credit:PA)
Soccer - Barclays Premier League - West Bromwich Albion v Sunderland - The Hawthorns(32 of50)
Football fans shield their eyes from the bright sunshine as West Bromwich Albion play Sunderland in the Barclays Premier League match against at The Hawthorns, West Bromwich. (credit:PA)
Soccer - Barclays Premier League - West Bromwich Albion v Sunderland - The Hawthorns(33 of50)
Sunderland's Adam Johnson shoots past West Bromwich Albion's Jonas Olsson but fails to score,during the Barclays Premier League match at The Hawthorns, West Bromwich. (credit:PA)
Soccer - Barclays Premier League - West Bromwich Albion v Sunderland - The Hawthorns(34 of50)
West Bromwich Albion's Stephane Sessegnon (centre) celebrates scoring his teams first goal with Nicolas Anelka (left) and Scott Sinclair (right),during the Barclays Premier League match at The Hawthorns, West Bromwich. (credit:PA)
Soccer - Barclays Premier League - West Bromwich Albion v Sunderland - The Hawthorns(35 of50)
West Bromwich Albion's Stephane Sessegnon (right) celebrates scoring his teams first goal with Nicolas Anelka (left), during the Barclays Premier League match at The Hawthorns, West Bromwich. (credit:PA)
Soccer - Barclays Premier League - West Bromwich Albion v Sunderland - The Hawthorns(36 of50)
Sunderland manager Paulo Di Cannio watches his team against West Bromwich Albion, during the Barclays Premier League match at The Hawthorns, West Bromwich. (credit:PA)
Soccer - Barclays Premier League - West Bromwich Albion v Sunderland - The Hawthorns(37 of50)
West Bromwich Albion's stephane Sessegnon battles for the ball with Sunderland's Ki Sung Yeung during the Barclays Premier League match at The Hawthorns, West Bromwich. (credit:PA)
Soccer - Barclays Premier League - West Bromwich Albion v Sunderland - The Hawthorns(38 of50)
Sunderland manager Paulo Di Cannio watches his team with West Bromwich Albion manager Steve Clarke (right) during the Barclays Premier League match at The Hawthorns, West Bromwich. (credit:PA)
Soccer - Barclays Premier League - West Bromwich Albion v Sunderland - The Hawthorns(39 of50)
Sunderland manager Paulo Di Cannio watches his team with West Bromwich Albion manager Steve Clarke (right) during the Barclays Premier League match at The Hawthorns, West Bromwich. (credit:PA)
Soccer - Barclays Premier League - West Bromwich Albion v Sunderland - The Hawthorns(40 of50)
Sunderland manager Paulo Di Cannio (left) watches his team with West Bromwich Albion manager Steve Clarke during the Barclays Premier League match at The Hawthorns, West Bromwich. (credit:PA)
Soccer - Barclays Premier League - West Ham United v Everton - Upton Park(41 of50)
Everton's Romelu Lukaku and Phil Jagielka (right) after the final whistle. (credit:PA)
Soccer - Barclays Premier League - West Ham United v Everton - Upton Park(42 of50)
Everton's Romelu Lukaku throws his shirt into the crowd after the final whistle. (credit:PA)
Soccer - Barclays Premier League - West Ham United v Everton - Upton Park(43 of50)
Everton's Romelu Lukaku (right) celebrates with his team-mates after the final whistle. (credit:PA)
Soccer - Barclays Premier League - West Ham United v Everton - Upton Park(44 of50)
Everton's Leighton Baines celebrates scoring his side's second goal (credit:PA)
Soccer - Barclays Premier League - West Ham United v Everton - Upton Park(45 of50)
West Ham United's Mark Noble celebrates scoring his side's second goal (credit:PA)
Soccer - Barclays Premier League - West Ham United v Everton - Upton Park(46 of50)
West Ham United's Winston Reid (left) and Everton's Kevin Mirallas battle for the ball (credit:PA)
Soccer - Barclays Premier League - West Ham United v Everton - Upton Park(47 of50)
Everton's Ross Barkley competes for the ball with West Ham United's Razvan Rat during the Barclays Premier League match at Upton Park, London. (credit:PA)
Soccer - Barclays Premier League - West Ham United v Everton - Upton Park(48 of50)
Everton's Ross Barkley (left) and West Ham United's Joey O'Brien battle for the ball (credit:PA)
Soccer - Barclays Premier League - West Ham United v Everton - Upton Park(49 of50)
West Ham United's Ravel Morrison scores the opening goal of the game with Mark Noble (right) (credit:PA)
Soccer - Barclays Premier League - West Ham United v Everton - Upton Park(50 of50)
West Ham United's Ravel Morrison scores the opening goal of the game with Mark Noble (right) (credit:PA)
Newcastle too lost 2-3 at home having led twice. Loïc Rémy hit two on his home debut but Hull fought back through Robbie Brady and Ahmed Elmohamady, before Sone Aluko gave Steve Bruce's team their first win on the road this term.
West Brom trounced Sunderland 3-0 for their first victory as the pressure mounts on Paolo di Canio. Stéphane Sessègnon scored on his debut versus his former club while Liam Ridgewell and Morgan Amalfitano were also on target.
In the early kick-off, Brad Guzan saved a Robert Snodgrass penalty and Libor Kozák came off the substitutes' bench to give Aston Villa their first three points since the opening day.