In the new series of the ITV programme the Geordie duo dress up to fool unsuspecting celebrities.
Their latest target is journalist Piers and the Geordie duo teamed up with Simon Cowell to catch him out.
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Piers, 47, comes to music mogul Simon's office where he's shown a black dot on a white canvas and told it is a valuable artwork.
Simon discusses how much it is worth with Dec, disguised as an Eastern European art trader and Ant, his guard.
They come up with the figure of £450,000 but when Piers is left alone in the office he gets a shock as the canvas comes crashing down at his feet.
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He jumps up, shouting "Jesus!", and is then blamed for the accident before Ant and Dec admit it's a joke, saying: "Relax Piers, you are not getting arrested."
Piers said: "I genuinely didn't recognise Ant and Dec."
Last week's victims of the Geordie pranksters were One Direction who thought they were meeting super fans from New Zealand.
The Piers prank will be shown this Saturday on ITV.
The two 'TOWIE' boys were basically inseparable before Mark left the show this year. Their foolish capers were one of the best parts of the show but Arg has taken up the mantle of TOWIE's resident laddish ladies man since his bezzie vacated the position. (credit:Getty Images)
Dale Winton and David Walliams(02 of10)
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In what could be the the campest bromance in celebville, perma-tanned TV presenter Dale and 'Little Britain' star David Walliams are the best of mates and are often spotted dining out together. (credit:WENN)
Matt Cardle and Aiden Grimshaw(03 of10)
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The two former 'X Factor' contestants bonded a lot during their time on the show, which Cardle won in 2010. Grimshaw started strongly but came a disappointing ninth! (credit:Getty Images)
George Clooney and Brad Pitt(04 of10)
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Brad Pitt and George Clooney go way back and are widely recognised as best friends off the screen too. The partners-in-crime have been in four films together and also teamed up to start a charity. (credit:AP)
Ben Affleck and Matt Damon are, like Clooney and Pitt, very close, having written 'Good Will Hunting' together, which won them an Oscar, and are planning to continue making movies together. (credit:AP)
Ant and Dec(07 of10)
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Where would British television presenting be without the veteran Geordie boys? Who else could we trust to laugh sheepishly at weird people on Britain's Got Talent? They've been in the biz for over twenty years together and can STILL stand the sight of each other - they even live around the corner from one another. (credit:PA)
Kanye West and Jay-Z(08 of10)
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Two supremely talented artists combined to form one rap supergroup this year for the album 'Watch The Throne', which finally united Jay-Z and Kanye West together on record. The duo, two of the most powerful me in music, are best of buds too! (credit:Getty Images)
Tom Felton and Rupert Grint(09 of10)
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They might be mortal enemies in the films, but Ron Weasley and Draco Malfoy - or rather, Rupert Grint and Tom Felton are the best of friends off-screen. Grint even wore a 'I Love Tom Felton' t-shirt on the red carpet at one premiere. (credit:Alamy)
Ed Westwick and Chace Crawford(10 of10)
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Ed, centre, and Chace, right, two-thirds of the male contingent of Gossip Girl have propped up the hot, well-spoken rich male TV trope all on their own for the past few years - both on and off screen. Good men. (credit:AP)
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Ant and Dec tease the new series of 'Britian's Got Talent' in the video below...