The Queen guitarist was appearing on a trailer for the latest edition of the show alongside wife Anita Dobson - who is a panellist - when the incident happened.
Open Image Modal
Brian May jokingly stormed off 'Loose Women'
However, the ‘stage storm’ was all in good humour, as he jokingly left his seat at the desk when co-host Jane Moore asked him: "Do you have any idea what you've let yourself in for?"
"What was I thinking?" he said, as he got up and left his stool.
Brian was an honorary Loose Man following his win at the Classic Rock Awards on Wednesday night, where he picked up Living Legend gong for his services to the music industry.
Open Image Modal
Brian was appearing on the show alongside wife Anita Dobson
When he returned to the panel during the show, Brian and Anita spoke about how they got together, revealing he was still married at the time.
"I was the scarlet woman. I'm not proud of it," the former ‘EastEnders’ actress admitted.
Brian added that his late bandmate Freddie Mercury told him that their relationship would never last because Anita was an actress.
Watch the couple talk more about their marriage in the video below:
‘Loose Women’ airs weekdays at 12.30pm on ITV.
12 Stars You'd Forgotten Were 'Loose Women'
Karren Brady(01 of12)
Open Image Modal
Long before she was answering to Lord Sugar, 'The Apprentice' star Karren was letting loose on the ITV daytime show. She was one of the original line-up of ladies, appearing on the first episode in 1999. However, her stint was short lived, as she left just a year later. (credit:REX)
Kerry Katona(02 of12)
Open Image Modal
Back when she was Kerry McFadden (those were the days, eh?), the Atomic Kitten singer appeared as a panelist between 2003 and 2004. She was only 23 when she joined the show, making her the youngest 'Loose Woman' regular ever, and her sometimes naive outlook on life meant she often clashed with Sherrie Hewson, providing many hilarious moments. (credit:REX)
Nina Wadia(03 of12)
Open Image Modal
She's best known for playing the opinionated Zainab Masood in 'EastEnders', but Nina offered up plenty of opinions of her own when she appeared as a series regular between 2005 and 2006. She later returned as a guest panelist for one episode in 2015. (credit:REX)
Gillian Taylforth(04 of12)
Open Image Modal
Another 'EastEnder' who graced the 'Loose Women' panel was Gillian - better known as Walford's Kathy Beale. The actress enjoyed two stints as a Loose lady - one in 2006 and another in 2008. (credit:REX)
Sarah Millican(05 of12)
Open Image Modal
In our humble opinion, Sarah's tenure as a 'Loose Woman' was simply not long enough. The comic only appeared as a panelist for less than a year in 2011, before leaving to concentrate on her stand-up career. (credit:REX)
Beverley Callard(06 of12)
Open Image Modal
During one of her many breaks from 'Coronation Street', Beverly (aka Liz McDonald) took up a seat behind the famous desk in 2010. (credit:REX)
Kym Marsh(07 of12)
Open Image Modal
While Kym has recently enjoyed a few turns as a guest panelist, many have forgotten her original stint as a regular on the show in 2005, back when she sported an interesting (if that's the right word?) set of hair extensions. (credit:REX)
Claire Sweeney(08 of12)
Open Image Modal
The former 'Brookside' actress enjoyed over two years on the panel back in 2003, and later returned for six episodes in 2010, and a further two in 2012. (credit:REX)
Cilla Black(09 of12)
Open Image Modal
While the late Cilla will be remembered for her huge TV hits 'Blind Date' and 'Surprise Surprise', her last regular TV gig was actually as a 'Loose Woman'. She appeared first as a guest anchor in 2009 and was invited back as a regular panelist between 2010 and 2011, returning for a one-off appearance in 2014. (credit:REX)
Sheree Murphy(10 of12)
Open Image Modal
Sheree was a welcome addition to the panel in 2006, after she finished playing Emmerdale's much-loved Tricia Dingle. While she left in 2007, she later returned as a guest panelist for an episode in 2015. (credit:REX)
Claire Richards(11 of12)
Open Image Modal
After the departure of many of Loose Women's biggest names in 2013 and 2014, Steps singer Claire made a string of guest appearances. She impressed bosses so much, she was soon promoted to a regular. However, a massive revamp of the show in the September of 2014 saw her leave the show with no explanation. (credit:REX)
Jenny Powell(12 of12)
Open Image Modal
The 'Wheel Of Fortune' assistant was finally given a break from turning around letters on a board in 2004, when she joined the 'Loose Women' panel for a year. (credit:ITV)